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Linked Editorial

Antidepressant induced weight gain

Linked Opinion

Antidepressant therapy and risk of weight gain

Objective To evaluate the long term association between antidepressant prescribing and body weight.

Design Population based cohort study.

Setting General practices contributing to the UK Clinical Practice Research Datalink, 2004-14.

Participants 136 762 men and 157 957 women with three or more records for body mass index (BMI).

Main outcome measures The main outcomes were antidepressant prescribing, incidence of ≥5% increase in body weight, and transition to overweight or obesity. Adjusted rate ratios were estimated from a Poisson model adjusting for age, sex, depression recording, comorbidity, coprescribing of antiepileptics or antipsychotics, deprivation, smoking, and advice on diet.

Results In the year of study entry, 17 803 (13.0%) men and 35 307 (22.4%) women with a mean age of 51.5 years (SD 16.6 years) were prescribed antidepressants. During 1 836 452 person years of follow-up, the incidence of new episodes of ≥5 weight gain in participants not prescribed antidepressants was 8.1 per 100 person years and in participants prescribed antidepressants was 11.2 per 100 person years (adjusted rate ratio 1.21, 95% confidence interval 1.19 to 1.22, P<0.001). The risk of weight gain remained increased during at least six years of follow-up. In the second year of treatment the number of participants treated with antidepressants for one year for one additional episode of ≥5% weight gain was 27 (95% confidence interval 25 to 29). In people who were initially of normal weight, the adjusted rate ratio for transition to overweight or obesity was 1.29 (1.25 to 1.34); in people who were initially overweight, the adjusted rate ratio for transition to obesity was 1.29 (1.25 to 1.33). Associations may not be causal, and residual confounding might contribute to overestimation of associations.

Conclusion Widespread utilisation of antidepressants may be contributing to long term increased risk of weight gain at population level. The potential for weight gain should be considered when antidepressant treatment is indicated.

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Northern Norway.

Lviv, Ukraine. Ukraine surprised me with its loveliness last year, and apparently I missed the most beautiful city of all: Lviv. From what I’ve seen it looks like Krakow and Ljubljana, two of my favorite European cities.

Lviv, Ukraine.

Corsica. This island south of the mainland in France has occupied my thoughts for a long time: its cliffs, its beaches, its food. I especially like that it isn’t overly discovered by international tourists. For now.


Cornwall, England. I consider myself an “accidental Anglophile” and have seen so much of Britain — but this southwest peninsula eludes me. It’s home to beaches that look like they’re part of the Mediterranean, and gorgeous rolling hills. Plus a cool pirate-y accent.

Cornwall, England.

Finnish Lapland. Finland is a county I love dearly, but I’ve only been in the summer. I think I’m overdue for a winter visit in Lapland — all the snow, all the ice swimming, all the early pink sunsets. And maybe a dogsled ride or two.

Finnish Lapland.

Fact: By the time I turned 33, I found my style. Tom Ford sunglasses , Zara leather jacket, silver earrings from El Salvador, dress from Albania. Pictured in Minsk.

Sweet Satisfaction

I feel very content right now with my travels. And that’s a bit unusual. Happiness is one thing; contentment is something different altogether. I’m used to feeling restless and driven, already planning my next trip (and let’s be realistic, one or two more trips) before I’ve even finished the first.

I feel very content right now with my travels.

For me, getting to my final country in Europe meant a lot to me. I’m going to be riding this pleasant buzzy feeling for a long time.

Stay tuned — I can’t wait to write a post about my absolute favorite places in Europe! Maybe the top 50 places overall, with special distinction for the top 10? I’ve been thinking about this!

What is one of your special travel achievements?
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Posted by Kate McCulley on Tuesday, June 19, 2018 at 6:00 amFiled under · Tagged with europe

June 19, 2018 at 11:31 AM

For me, it is visiting the places in my favorite books. I read several books about Scotland (including Outlander..yea I love that series) and ended up visiting all the regions in the books I read. Fell in love with The Paris Wife, and visited and stayed in the neighborhood of Hemmingway. Also read Labyrinth by Kate Mosse, and needed to visit the region of the Cathars (completed last year!). I think its fun when you fall in love with a place just by words, and then have that love be realized in front of you.

Isabella Eckert

You were the one who was always in detention, weren’t you?

Preconceived ideas about private school will include the Daddy’s girls who always get their way, and the rebels who insist on smoking behind the boarding house. But there is more to private school girls than that, and if you went there, you’ll have undoubtedly come across every single one of these.

It was for drinking, I think. Or having sex at school, or smoking. You’re not entirely sure because she’s never really said, and you’ve never really had the courage to ask her outright. There’s just an air of mystery around her.

She’s on an ‘All Rounder’ scholarship -academic, sports and music– but her parents forfeited it because they don’t really need it. She’s often jetting off to Monaco over half term, and went on safari over easter, right before exams. She still managed toget 6 A*s at A-Level.

She went under the radar until year 11. Over the summer she grew boobs and dyed her hair and all of a sudden the boys realise she’s a catch and compete for her affections.

Chloe spent every weekend with her older boyfriend in London and came back “sooo hungover”. She was probably the fittest girl in your year – too fit for the boys in your year. It’s not until years later you realise how creepy it is he was going out with her.

The one who was always in detention – or worse yet, the headmaster’s office

Whether she’s skipping period one or is drunk during rounders practice, she isin trouble. Somehow, though, she smiles her way out of it.

CCF, hockey, drama, choir, debating. You name it, she was doing it.

Who you knew you should like but really, you just wanted to punch her in the face. Repeatedly.

She had a diamond in her tooth and loads of cash in her dorm.

The one who wears loads of eyeliner and concealer lips

Along with five layers of mascara. It’s a wonder she could open her eyes.

She wore tweed at the weekends even though there were no fields in sight. You liked her, but you’re pretty sure she would have rather been hanging out with her horse, Tilly, than you.

Sweet and innocent looking on the surface – all the teachers think she’s a darling. But really, she’s sending profanities and naughty pictures to all the boys over MSN.

The one(s) with the combover

Come on, we all did it.

The one whose parents have a house in Spain

Meaning she has a and chills there during study leave. It’s okay though because you’ll all go together the summer of your GCSEs, get really drunk and have the best time ever, woooo Javea 2008!!!

The one who only drinks bottled water

No, it doesn’t taste that much better, but her mum still packs her off to school with a crate of it each week.

The prefect who took her role too seriously

“Someone has switched the name tags on all the year nine’s bag’s during chapel”, she says with tears in her eyes. Leave the discipline to the teachers, Annie.

The one who’s always late back from ‘town leave’

Ah, town leave, your two hours of freedom on a Saturday night. There was always one staggering in half-an-hour late and getting ‘gated’ the next weekend.

The one with the younger boyfriend

This was unconventional. Sure, when you were in year nine your best friendwent out with a guy in upper sixth. But this time, you’re in upper sixth and she’s getting with a 14-year-old, living that cougar life at the prime age of 17.

Shewas a fourth generation attendee, and the teachers all loved her because her older brother and sister were both clever charming. She was a leaf out the ol’ book. The really old teachers taught her father. Her Granddad’s name is embossed into the new science block’s wall.

She wasn’t even at uni yet but she’d already begun saying things like ‘fuck the system’ and dyeing her hair unauthorised colours like purple.

She has every colour of gel pen, including the sparkly ones. Her revision notes are perfectly colour coordinated.

Who’s now married – I wonder why.

The one who didn’t reallybelong to a girl gang

Everyone likes her, but she also likes everyone – and this is her downfall. Pick a side, Amy.

The one who is literally late for everything

You don’t know how she functions – if you still know her she hasn’t changed at all.

The one who is always ‘going to fail’

Oh my gosh she’s done “no work whatsoever!” She’s crying as she leaves the exam hall and you’re thinking, well she’s super clever, so I must have done alright. Results day comes: she’s nailed an A* and you got a C.

Her name was shortened to something ending with a ‘z’ and all the boys in your year fancied her.

We were this disrespectful when we were in year nine.

The ‘naturally blonde’one

Her bright, brighthair is swept over to one side. She’ll claim it’s been “lightened by the sun”, but you know better.

She’d often tell them she fancied them in front of everyone in class when she got bored. They’d have to file a report after the lesson.

The one who everyone picks on

There’s one in every girl gang. Her nickname is something like ‘Gammy’. Even though she’s clever and pretty she just draws mockery to her.

She’s not a loud, screechy bitch as cliches would lead you to believe. She’s quiet and cunning, and Girl World gravitates around her. The girls want to be her, the guys want to be with her – everyone is intimidated by her.

This may be one person, it may be eight, desperately seeking the approval of the Queen Bee. Secretly, though, they bitch about her when she isn’t there.

The girl who had a car at school

She would take you to McDonald’s at the weekend and you’d drive to games with music full-blast.

The one who always ‘got it wrong’ at the house dinners

Her friend two years above bought loads of wine for her and now she’s on the floor. You have to hide her from teachers before she gets housed. Or worse – runged.

The one who’s always housed

Jenny, stop smoking in the car park next to the science block! You keep getting caught!!

The girlwho gets suspended for getting runged three times

And it’s a massive deal. Some of you cry when she leaves.

She’ll get invited to all the 18ths, and bring you along. It will be the most highly-anticipated and highly disappointing evening of your year.

The one who showedyou how to roll up your skirt properly

She also wore eyeshadowinand she is your style idol.

The outrageouslysporty one

She’s somehow the captain of 1st team hockey, netball and tennis. She’s also training for GB triathlon/lacrosse/swimming at the next olympics. She’ll eat endlessly because she has to restore the nutrients from her two swims before lunch.

The one who’s destined for an artfoundation

Soon she’ll have an undercut hairstyle, and will wear things that make you feel utterly boring.

The ones who went on all the school trips

Guys they aren’t compulsory.

She was always angry and everyone was scared of her.

The one who gets a kick out of making the teachers’ lives hell

She’ll have her phone confiscated in every class, but that’s okay because she’ll just pass notes instead. In one lesson, towards the end of the year, she’ll tell the teacher in front of everyone they’re terrible at teaching and make them cry. It will be awkward.

Her Instagram is a thing of wonder, full of food from restaurants you could never dream of going to, and her crep collection is amazing.

The one who’s ‘really good at doing hair’

You’ll all queue up before each house dinner or ball, asking her to work her magic. The result will always include quiffs and/or plaits.

The one who’s ‘new’

She arrived in year ten and everyone wants to know stuff about her. Where did she come from? Why did she leave her old school? Which group will she slot into?

And fluorescent bras, and act disgusted when told by male teachers to fix it.

She is beautiful and her mum takes her on yoga weekends. She couldn’t harm a fly and all the boys are in love with her. But she never gets with any of them, because one of her friends fancies them. She is too pure for this world.

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The environs of Creil (Oise) and Chteau-Landon (Seine-et-Marne) are noted for their freestone (pierre de taille), which is also abundant at Euville and Lrouville in Meuse; the production of plaster is important in the environs of Paris, of kaolin of fine quality at Yrieix (1-Jaute-Vienne), of hydraulic lime in Ardche (Le Teil), of lime phosphates in the department of Somme, of marble in the departments of HauteGaronne (St Beat), Hautes-Pyrnes (Campan, Sarrancolin), Isre and Pas-de-Calais, and of cement in Pas-de-Calais (vicinity of Boulogne) and Isre (Grenoble).
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